Brain tumor

Deep topographic proteomics of a human brain tumour The cellular composition and spatial organization of tissues play a crucial role in determining their identity and function. Understanding these features is essential for studying disease outcomes. Recent advancements in spatially-resolved sequencing technologies have allowed for the characterization of gene expression patterns within tissues. However, to fully comprehend tissue heterogeneity, it is also necessary to consider the proteins encoded by the genes. Mass spectrometry imaging (MSI) techniques can map protein distribution in tissues but have limitations in generating comprehensive proteome data.